One thing I can tell you (although not from experience) is to not give up when doors are closed. I have heard over and over that some writers have had to go to over 30 publishers before someone agreed to publish their work. And these were works that went on to become widely acclaimed.
A publisher has many reasons for saying "no" but only one of them has to do with the quality of your work. The decision not to publish, way more often than not has little to do with the quality of your work. Fall out of love with what you have written and treat getting it published as the job that it is and if you believe in yourself and in your work, someone will publish it.
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