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The mini horse tells us that you don't necessarily need mutation to vastly change a species.
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Uh, and exactly what do you think cause the small size other than a mutation? Actually it could be multiple mutations that all worked together to make an exceptionally small horse based on the parents or it could be a spontaneous germline mutation that occured with just this horse. Either way, the tiny horse does not have the same wild type genes as the big horse.