UNDER CONDITIONAL MITIGATION
Join Date: Mar 2004
Location: Austin, TX
Posts: 20,012
|
When they are actually tested, a huge percentage of children with autism are found to have mitochondrial dysfunction (see below for relevant references.) Of course, the only people who will test them for this are the people who believe in the vaccination connection. Everyone else says, "No, we won't run a test for mitochondrial dysfunction, because we know your child has autism, not mitochondrial dysfunction." And when autistic individuals are confirmed beyond a shadow of a doubt to have mitochondrial dysfunction (e.g. Hannah Poling,) suddenly it becomes evidence that they never had autism to begin with.
Pastural E, et al. Novel plasma phospholipid biomarkers of autism: Mitochondrial dysfunction as a putative causative mechanism. Prostaglandins Leukot Essent Fatty Acids. 2009 Oct;81(4):253-64.
Clark-Taylor T, Clark-Taylor BE. Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial beta-oxidation by long chain acyl-CoA dehydrogenase. Med Hypotheses 62(6): 970-5.
Filipek PA, Juranek J, et al. Mitochondrial dysfunction in autistic patients with 15q inverted duplication. Ann Neurol 53(6): 801-4, 2003.
Fillano JJ, Goldenthal MJ, et al. Mitochondrial dysfunction in patients with hypotonia, epilepsy, autism, and developmental delay: HEADD syndrome. J Child Neurol 17(6): 435-9., 2002.
Gargus JJ, Imtiaz F. Mitochondrial energy-deficient endophenotype in autism. Am J Biochem Biotechnol 4(2): 198-207, 2008.
Holtzman D. Autistic spectrum disorders and mitochondrial encephalopathies. Acta Paediatr.2008 Jul;97(7):859-60.
Lerman-Sagie T, et al. Should autistic children be evaluated for mitochondrial disorders. J Child Neurol 19(5): 379-81, 2004.
Lombard, J. Autism: a mitochondrial disorder? Med Hypotheses 50(6): 497-500, 1998
Oliveira G, Diogo L, et al. Mitochondrial dysfunction in autism spectrum disorders: a population-based study. Dev Med Child Neurol 47(3): 185-9, 2005.
Palmieri L, et al. Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1. Mol Psychiatry. 2010 Jan;15(1):38-52.
Palmieri L, Persico AM. Mitochondrial dysfunction in autism spectrum disorders: Cause or effect? Biochim Biophys Acta. 2010 May.
Poling JS, et al. Developmental regression and mitochondrial dysfunction in a child with autism. J Child Neurol 21(2): 170-2, 2006.
Pons R, Andreu AL, et al. Mitochondrial DNA abnormalities and autistic spectrum disorders. J Pediatr 144(1): 81-5, 2004.
Ramoz N, Reichert JG, et al. Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. Am J Psychiatry 161(4): 662-9, 2004.
Rossignol DA, Bradstreet JJ. Evidence of mitochondrial dysfunction in autism and implications for treatment. A J Biochem Biotechnol 4(2): 208-217, 2008.
Segurado R, Conroy J, et al. Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31. Am J Psychiatry 162(11): 2182-4, 2005.
Silverman JM, Buxbaum JD, et al. Autism-related routines and rituals associated with a mitochondrial aspartate/glutamate carrier SLC25A12 polymorphism. Am J Med Genet B Neuropsychiatr Genet, 2007.
Shoffner J, et al. Fever Plus Mitochondrial Disease Could Be Risk Factors for Autistic Regression. J Child Neurol. 2009 Sep 22.
Smith M, Spence MA, Flodman P. Nuclear and mitochondrial genome defects in autisms. Ann. N.Y. Acad. Sci. 1151:102–132, 2009.
Weissman JR, et al. Mitochondrial disease in autism spectrum disorder patients: a cohort analysis.PLoS ONE.2008;3(11):e3815.
|